The Metropolitan Police says it is aware of the latest release of files related to Jeffrey Epstein and confirms it has received "a number of reports relating to alleged misconduct in a public office".
It comes after emails appeared to show conversations between Lord Mandelson and Epstein about government and political matters while the former was serving as business secretary and the de-facto deputy prime in 2009, in Gordon Brown's government.
Ella Marriott, Commander of the Met, said: "The reports will all be reviewed to determine if they meet the criminal threshold for investigation.
"As with any matter, if new and relevant information is brought to our attention we will assess it, and investigate as appropriate."
It comes after documents were released by the US Department of Justice as part of millions of files relating to Epstein.
Following the release, Mandelson has been accused of giving paedophile financier Epstein advanced notice of a €500bn EU bank bailout in 2010.
The 72-year-old has also been accused leaked sensitive UK government tax plans to Epstein.
The SNP, Lib Dems, and Plaid Cymru have all called for a formal police inquiry into the allegations.
Lord Mandelson, who earlier resigned his membership of the Labour Party, has been approached for comment.
On his relationship with Epstein he has previously said: "I was wrong to believe Epstein following his conviction and to continue my association with him afterwards. I apologise unequivocally for doing so to the women and girls who suffered."