In an unusually direct appeal, Pope Leo decried the conditions for Palestinians in Gaza during his Christmas sermon today.
The first US pope highlighted the story of Jesus's birth - the reason Christmas is celebrated by Christians - which he said showed God "pitched his fragile tent" among the people of the world.
"How, then, can we not think of the tents in Gaza, exposed for weeks to rain, wind and cold?"
This is his first Christmas since succeeding the late Pope Francis, and he usually strikes a more quiet and diplomatic style.
But the new pope has lamented conditions in Gaza several times recently, telling journalists last month the only solution is to include a Palestinian state.
Later today, the pope will deliver a biannual "Urbi et Orbi" (to the city and the world) message and blessing, which usually addresses global conflicts.
If you want to watch the pontiff's first Christmas mass at the Vatican, we've got you covered with this live stream...